Search results for "Aneuploid Cells"
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Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts.
2006
Alterations in the number and/or morphology of centrosomes are frequently observed in human tumours. However, it is still debated if a direct link between supernumerary centrosomes and tumorigenesis exists and if centrosome amplification could directly cause aneuploidy. Here, we report that hydroxyurea treatment induced centrosome amplification in both human fibroblasts expressing the HPV16 -E6-E7 oncoproteins, which act principally by targeting p53 and pRB, respectively, and in conditional pRB deficient mouse fibroblasts. Following hydroxyurea removal both normal and p53 deficient human fibroblasts arrested. On the contrary pRB deficient fibroblasts entered the cell cycle generating aneupl…
Aneuploidy as a consequence of senescence and ovariectomy in the golden hamster (Mesocricetus auratus).
1978
The hypothesis of the preferred X-chromosome loss in elder human females was reevaluated in the golden hamster: early castration of females proved that the increase of aneuploid cells is correlated with the loss of the ovaries. But here, and in old females, aneuploidy consisted of random loss of excess of chromosomes, in no case an X-chromosome.